Clinical Trials

For more information about clinical trials, please refer to the National Institutes of Health (NIH) overview of the clinical trial process, available at or by clicking on the Protocol ID and NCI Study below.

Laromustine (Cloretazine®, VNP40101M)
Protocol ID Title Sites
CLI-043 Phase II Study of laromustine (Cloretazine®, VNP40101M) for Elderly Patients with de novo Poor Risk Acute Myelogeous Leukemia 3 Sites
NVC-021* Dose Escalation Trial of laromustine (Cloretazine®, VNP40101M) and Hematopoietic Cell Transplantation for Patients with Selected, Poor-Prognosis Hematologic Malignancies 1 Site
NVC-022* A Phase I/II Trial of laromustine (Cloretazine®, VNP40101M) and Temodar® (Temozolomide) for Patients with Malignant Gliomas in 1st Relapse or Progression 1 Site
NVC-023* A Phase I/II Evaluation of Laromustine (VNP40101M), A Solfonylhydrazine Alkalating Agent, Combined with Infusional Cytarabine in Elderly Patients with Acute Myeloid Leukemia and High Risk Myelodysplastic Syndrome 1 Site
* Investigator initiated trial

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Sponsored by the National Institute of Health (NIH)
NCI Study Title Sites
6254 Phase II Study of Triapine® in Combination with Gemcitabine in Adenocarcinoma of the Biliary Ducts and Gall Bladder 1 Site
7043 A Phase I Study of a Prolonged Infusion of Triapine in Combination with a Fixed Dose Rate of Gemcitabine in Patients with Advanced Solid Tumors and Lymphomas 10 Sites
7044 A Phase I Study of Triapine® in Combination with Radiation Therapy in Locally Advanced Pancreas Cancer 1 Site
7225 A Phase I and Pharmacokinetic Study of Oral Triapine® in the Treatment of Advanced Solid Tumors 6 Sites
7336 Phase I Study of Intravenous Triapine® in Combination with Pelvic Radiation Therapy with or without Weekly Intravenous Cisplatin Chemotherapy for Locally Advanced Cervical, Vaginal, or Pelvic Gynecologic Malignancies 1 Site
7704 Phase II Study of Triapine® and Plus Fludarabine in Treating Patients With Myeloproliferative Disorders, Including Chronic Myelomonocytic Leukemia, or Accelerated Phase or Blastic Phase Chronic Myelogenous Leukemia 1 Site